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Bohemian Trastevere is one of Rome’s most historic and picturesque neighborhoods—a maze of cobbled streets lined with atmospheric restaurants serving some of Italy’s best cuisine. At dusk, trendy crowds pour into its fashionable sidewalk cafés and bars to enjoy the vibrant Roman nightlife. Trastevere lies across the river—hence the name, which means “across the Tiber”—from the center of Rome, and at its heart is Piazza Santa Maria in Trastevere, home to one of Rome’s oldest churches (from AD 340) and a majestic 15th-century fountain. Other neighborhood sights include the beautiful Santa Cecilia in Trastevere church, dating from the fifth century, and Villa Farnesina, filled with stunning frescoes—including two attributed to Raphael.