Home to architectural gems such as the Leaning Tower of Pisa, Renaissance masterpieces including Michelangelo’s “David,” and some of the world’s finest wine, Tuscany is one of the world’s most visited regions—for good reason. The capital of Florence, also known as the Cradle of the Renaissance, boasts two of the world’s most significant (and busiest) art museums: Uffizi Gallery and Accademia Gallery (Galleria dell'Accademia). You can spend hours lining up outside, but in-the-know travelers get ahead of the crowd with skip-the-line tickets and early-access or after-hour tours. In Pisa, beat the timed-entry system for the Leaning Tower of Pisa with a tour, or see beyond the sights of Piazza dei Miracoli on a guided bike ride. Head to San Gimignano and Siena, both popular stops on day trips from Florence, and lose yourself in the charming historic centers for which they are famed. For a true taste of Tuscany, head for the region’s top gastronomic destinations and enjoy a cooking class in Lucca or Arezzo, paired with wine tasting in Chianti, Montepulciano, or Montalcino. Tuscany wine tours include samples of local vintages and allow you to hop from winery to winery without worrying about transportation or choosing where to go.