Along the opposite side of Santo Spirito, the San Frediano neighborhood was once a sleepy residential quarter. Today, it’s still home to many native Florentines and their beloved corner alimentari (food shops), and family-run artisan workshops, although the past decade has brought more fashionable (and more expensive) restaurants and shops to the district.
If you love browsing antiques and artisan crafts, this is a great neighborhood for wandering, with very little tourist traffic to detract from its authentic vibe. Be sure to visit the gorgeous Cappella Brancacci, often referred to as the Sistine Chapel of the early Renaissance.