Woven into the rich cultural tapestry of Guadalajara, Mexico’s second-largest city, are tequila distilleries, colonial architecture, Maya ruins, and world-class museums. The lively metropolis—which is actually comprised of three separate cities: Tlaquepaque, Zapopan, and official Guadalajara—serves as an equally dazzling and less daunting alternative to Mexico City’s overwhelming sprawl. Guadalajara Historic Center (Centro Historico) is crowned by Plaza Tapatia and studded with fountains and sculptures, and serves as an excellent people-watching spot—venture inside the Instituto Cultural Cabanas, and you’ll find world-famous frescoes by Jose Clemente Orozco. A tour is an ideal way to see Guadalajara’s many dispersed monuments, including the must-visit Guadalajara Cathedral and the Governor's Palace, as well as Tlaquepaque’s market of traditional Mexican handicrafts. For something even more intoxicating, take a ride on the Jose Cuervo Express train, destined for tequila distilleries and abundant samples of Mexico’s national drink; or watch a lucha libre (Mexican wrestling match) over tacos and beer. When you’re finally ready for a city break, take a day trip to Lake Chapala (Lago de Chapala), Mexico’s largest natural lake; the conical pyramids of Guachimontones, a UNESCO World Heritage Site; or the artisan villages of Jalisco, where the surrounding landscape offers stunning fields full of blue agave.