For the morning portion of your tour, meet your guide and small group of fellow travelers outside of Oppio Caffè. Skip the long lines with your fast access tickets and proceed directly inside to begin exploring the ancient world's epic sports arena. Listen as your guide describes the harrowing contests that took place there.
Head over to the Roman Forum, where you'll climb up a nearby overlook to get a peek inside instead of slogging through the crowds awaiting entrance. From your vantage point, you can see the Temple of the Vestal Virgins and the Senate House, and your guide will help you imagine how the forum functioned as the center of Rome's society two millennia ago.
Step inside the Pantheon, the largest un-reinforced concrete dome in the world, and hear how it was built. Then head for the Trevi Fountain and Piazza Navona, streets made famous in the film Roman Holiday, with a gelato in hand.
Take a break for lunch on your own, then meet your guide in Piazza del Risorgimento Square. Enjoy skipping the lines again and head inside for a curated tour of the Vatican's highlights, during which you'll see the Laocoön Group, the sculpture galleries and the Raphael Rooms. End up in the Sistine Chapel, gazing upwards at Michelangelo's famous frescoes.
From there, choose between extending your stay in the chapel and the Vatican Museums, or skip the lines and enter St. Peter’s Basilica directly from the Sistine Chapel.