You'll catch glimpses of the red-tiled dome of the Duomo, or Cathedral of Santa Maria dei Fiori, peeping over the rooftops as soon as you arrive in Florence.
The 13th-century Sienese architect Arnolfo di Cambio was responsible for building many landmarks in Florence but this is his showstopper. The beautiful ribbed dome was creatively added by Brunelleschi in the 1420s.
The building took 170 years to complete, and the facade was remodeled to reflect Cambio’s design in the 19th century.
Inside the Duomo, your eyes are inevitably drawn upwards to that soaring painted dome and lovely stained-glass windows by such masters as Donatello. Visit the crypt, where Brunelleschi's tomb lies, or to the top of the enormous dome itself for stupendous views over Florence.