After pickup at your Istanbul hotel in the afternoon, drive in a climate-controlled coach along the Golden Horn.
The Golden Horn is a branch of the Bosphorous River that forms a natural harbor, and also separates the old part of Istanbul (Sultanahmet) from the new (Beyoglu).
Drive through the neighborhood of Balat to see the Church of St Stephen of the Bulgars, the Old Jewish Hospital (Or-Ahayim) and the Ecumencial Orthodox Patriarchate (aka Church of St George). Trace part of the miles-long Old City Walls of Constantinople, built by Constantine the Great in the 4th century AD to protect the capital of the Byzantine Empire.
Continue a short distance to Eminonu Pier where you transfer to a ferry for a 1.5-hour cruise along the Bosphorus River. See the Asian and European continents on either side of the river along with several Ottoman palaces, ancient fortresses and examples of typical Ottoman architecture.
Visit Eyup Sultan Mosque where the revered Ayyub al-Ansari Mausoleum is located and attracts Muslim pilgrims. Then take the cable car up the hill to Pierre Loti Cafe where you can enjoy a coffee and views over the Golden Horn before returning to your hotel.